Description
By (author) Voet Donald; By (author) Voet Judith G.
:
The “Gold Standard” in Biochemistry text books.
Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. It incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
Table of contents:
Guide to Media Resources xvi
Part I Introduction and background 1
Chapter 1 Life 3
1. The Origin of Life 3
2. Evolution of Cells 9
3. Biochemistry: A Prologue 18
4. Genetics: An Overview 23
Chapter 2 Aqueous Solutions and Bioenergetics 36
1. Properties of Water 37
2. Acids, Bases, and Buffers 40
3. First Law of Thermodynamics: Energy is Conserved 45
4. Second Law of Thermodynamics: The Universe Tends Toward Maximum Disorder 46
5. Chemical Equilibria 49
Appendix: Concentration Dependence of Free Energy 52
Part II Biomolecules 57
Chapter 3 Amino Acids 59
1. The Amino Acids of Proteins 59
2. Stereochemistry of Amino Acids 64
3. Chemical Properties of Amino Acids 69
4. “Nonstandard” Amino Acids 71
Chapter 4 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 75
1. Nucleotides and Nucleic Acids 76
2. DNA Is the Carrier of Genetic Information 78
3. Double Helical DNA 81
4. Forces Stabilizing Nucleic Acid Structures 95
5. Supercoiled DNA 101
6. Gene Expression and Replication: An Overview 113
7. Molecular Cloning 122
Chapter 5 Techniques of Protein and Nucleic Acid Purification 150
1. Protein Isolation 150
2. Protein Solubility 154
3. Chromatographic Separations 156
4. Electrophoresis 167
5. Ultracentrifugation 173
6. Nucleic Acid Fractionation 178
Chapter 6 Covalent Structures of Proteins and Nucleic Acids 184
1. Primary Structure Determination of Proteins 185
2. Chemical Synthesis of Polypeptides 196
3. Nucleic Acid Sequencing 201
4. Chemical Synthesis of Oligonucleotides 210
5. Chemical Evolution 214
6. Bioinformatics: An Introduction 223
Chapter 7 Three-Dimensional Structures of Proteins 241
1. Secondary Structure 241
2. Fibrous Proteins 253
3. Globular Proteins 260
4. Protein Stability 280
5. Quaternary Structure 288
Appendix: Viewing Stereo Pictures 292
Chapter 8 Protein Folding, Dynamics, and Structural Evolution 300
1. Protein Folding: Theory and Experiment 300
2. Folding Accessory Proteins 312
3. Protein Structure Prediction and Design 324
4. Protein Dynamics 328
5. Conformational Diseases: Amyloid and Prions 331
6. Structural Evolution 338
Chapter 9 Chemical and Biological Aspects of Hemoglobin 346
1. Hemoglobin and Myoglobin Function 346
2. Structure and Mechanism 355
3. Abnormal Hemoglobins 364
4. Allosteric Regulation 371
Appendix: Derivations of Symmetry Model Equations 377
Chapter 10 Sugars and Polysaccharides 382
1. Monosaccharides 382
2. Polysaccharides 388
3. Glycoproteins 396
Chapter 11 Lipids and Membranes 409
1. Lipid Classification 409
2. Lipid Aggregates and their Properties 416
3. Biological Membranes 421
4. Membrane Assembly and Protein Targeting 440
5. Lipoproteins 468
Part III MECHANISMS OF ENZYME ACTION 485
Chapter 12 Enzyme Kinetics 487
1. Historical Perspective 488
2. Substrate Specificity 489
3. Coenzymes 492
4. Control of Enzymatic Activity 493
5. A Prime
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