Description
By (author) Patrick Graham L.
Short /annotation:
The market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.
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Medication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, we have all become more familiar with drug production and distribution. However, do we really know what happens before those drugs are distributed? What”s the process behind drug discovery? How do our bodies interact with those chemicals? An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its student-friendly writing style makes this text an ideal tool for those coming to the subject for first time, but also for students looking to deepen their understanding.The book guides students through understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures in Part C. Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E. From principles to practice, accompanied by examples and case studies emerging from current biomedical research, the book will equip students with a robust understanding of medicinal chemistry, to prepare them for future success.
Table of contents:
1: Drugs and Drug Targets2: Protein Structure and Function3: Enzymes: Structure and Function4: Receptors: Structure and Function5: Receptors and Signal Transduction6: Nucleic Acids: Structure and Function7: Enzymes as Drug Targets8: Receptors as Drug Targets9: Nucleic Acids as Drug Targets10: Miscellaneous Drug Targets11: Pharmacokinetics and Related TopicsCase Study 1: Statins12: Drug Discovery: Finding a Lead13: Drug Design: Optimizing Target Interactions14: Drug Design: Optimizing Access to the Target15: Getting the Drug to MarketCase Study 2: The Design of ACE InhibitorsCase Study 3: Artemisinin and Related Antimalarial DrugsCase Study 4: The Design of OxamniCase Study 5: Fosfidomycin as an Antimalarial Agent16: Combinatorial and Parallel Synthesis17: In Silico Drug Design18: Quantitative Structure-Activity RelationshipsCase Study 6:De Novo Design of a Thymidylate Synthase Inhibitor19: Antibacterial Agents20: Antiviral Agents21: Anticancer Agents22: Protein Kinase Inhibitors as Anticancer Agents23: Antibodies and Other Biologics24: Cholinergics, Anticholinergics, and Anticholinestarases25: Drugs Acting on the Adrenergic Nervous System26: The Opioid Analgesics27: Anti-Ulcer Agents28: Cardiovascular DrugsCase Study 7: Steroidal Anti-Inflammatory AgentsCase Study 8: Design of a Novel AntidepressantCase Study 9: The Design and Development Of AliskirenCase Study 10: Factor Xa InhibitorsCase Study 11: Reversible Inhibitors of HCV NS-34A Protease
Review quote:
The best general undergraduate textbook on medicinal chemistry. This new edition retains the accessible style of writing, but provides important updates on the topics.
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I read this masterpiece to build a strong knowledge of medicinal chemistry and it has helped me a lot. I would definitely recommend it to others. Detailed explanations of enzyme-substrate interactions and much more are very useful.
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A very useful medical chemistry book and teaching tool. Great learning resources and easy to digest content.
Biographical note:
Dr Graham L. Patrick gained his BSc Honours at Glasgow Universi
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